Article
HLA-DR allele reading register shifting is associated with immunity induced by SERA peptide analogues.
Biochemical and biophysical research communications - 18 Jul 2008
Salazar Luz Mary, Bermúdez Adriana, Patarroyo Manuel E
Abstract excerpt
SERA protein is a leading candidate molecule to be included in an antimalarial vaccine. Conserved high activity binding peptides (HABP) binding to red blood cells (RBC) have been identified in this protein. One of them (6762) localising in the 18-kDa C-terminal fragment was used to induce protective immunity with negative result. Critical RBC binding residues (assessed by glycine-analogue scanning) were replaced...
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