Article
Production of recombinant human transthyretin with biological activities toward the understanding of the molecular basis of familial amyloidotic polyneuropathy (FAP).
Biochemistry - 5 Mar 1991
Furuya H, Saraiva M J, Gawinowicz M A, Alves I L, Costa P P, Sasaki H, Goto I, Sakaki Y
Abstract excerpt
Transthyretin (TTR) is a plasma protein interacting with thyroxine T4 and retinol binding protein (RBP). Several variants of TTR with single amino acid substitutions have been identified as the major components of the amyloid fibrils of familial amyloidotic polyneuropathy (FAP), a fetal, autosomal dominant genetic disease. The elucidation of the molecular nature of the variants distinct from that of the wild-type...
Topics
- Amino Acid Sequence
- Amyloidosis
- Base Sequence
- Cloning, Molecular
- Escherichia coli
- Female
- Genetic Variation
- Humans
- Male
- Molecular Sequence Data
- Mutagenesis, Site-Directed