Article
Aboard transthyretin: From transport to cleavage.
IUBMB life - 1 Jun 2010
Liz Márcia A, Mar Fernando M, Franquinho Filipa, Sousa Mónica M
Abstract excerpt
Transthyretin (TTR) is a plasma and cerebrospinal fluid protein mainly recognized as the transporter of thyroxine (T(4)) and retinol. Mutated TTR leads to familial amyloid polyneuropathy, a neurodegenerative disorder characterized by TTR amyloid deposition particularly in peripheral nerves. Beside its transport activities, TTR is a cryptic protease and participates in the biology of the nervous system. Several...
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