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Quantification of Human Opiate Receptor Concentration and Affinity Using High and Low Specific Activity [ <sup>11</sup> C]Diprenorphine and Positron Emission Tomography

1 Mar 1991

Abstract excerpt

[11C]Diprenorphine, a weak partial opiate agonist, and positron emission tomography were used to obtain noninvasive regional estimates of opiate receptor concentration (Bmax) and affinity (Kd) in human brain. Different compartmental models and fitting strategies were compared statistically to establish the most reliable method of parameter estimation. Paired studies were performed in six normal subjects using...

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PMID: 1847703
DOI: 10.1038/jcbfm.1991.52

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