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Article

Connective tissue growth factor is necessary for retinal capillary basal lamina thickening in diabetic mice.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society - 1 Aug 2008

Kuiper Esther J, van Zijderveld Rogier, Roestenberg Peggy, Lyons Karen M, Goldschmeding Roel, Klaassen Ingeborg, Van Noorden Cornelis J F, Schlingemann Reinier O

Abstract excerpt

Experimental prevention of basal lamina (BL) thickening of retinal capillaries ameliorates early vascular changes caused by diabetes. Connective tissue growth factor (CTGF) is upregulated early in diabetes in the human retina and is a potent inducer of expression of BL components. We hypothesize that CTGF is causally involved in diabetes-induced BL thickening of retinal capillaries. To test this hypothesis, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18474939
DOI: 10.1369/jhc.2008.950980
PMCID: PMC2443606

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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