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Article

Preservation of hepatic phenotype in lentiviral-transduced primary human hepatocytes.

Chemico-biological interactions - 17 Jun 2008

Zamule Stephanie M, Strom Stephen C, Omiecinski Curtis J

Abstract excerpt

Lentiviral vectors effectively transduce both dividing and non-dividing cells and stably integrate into the genome of the host cell. In this study, we evaluated the usefulness of a lentiviral system for genetic modulation of primary human hepatocyte cultures. Infection with GFP-expressing lentivectors shows that Huh7 and HepG2 cell lines, as well as primary cultures of human hepatocytes, are efficiently...

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Source

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Identifiers

PMID: 18468591
DOI: 10.1016/j.cbi.2008.03.015
PMCID: PMC2749468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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