Article
Identification of amino acid positions associated with neuraminidase activity of the hemagglutinin-neuraminidase glycoprotein of Sendai virus.
Virology - 1 Feb 1991
Gorman W L, Takahashi T, Scroggs R A, Portner A
Abstract excerpt
Identification of amino acid positions associated with neuraminidase activity on the hemagglutinin-neuraminidase (HN) glycoprotein of paramyxoviruses has been difficult because neuraminidase-inhibiting antibodies are not neutralizing and thus, escape mutants have not been isolated. Instead, many investigators have correlated an altered neuraminidase (NA) activity of natural virus variants, such as plaque-size...
Topics
- Amino Acids
- Animals
- Cell Line
- Electrophoresis, Polyacrylamide Gel
- Genetic Variation
- HN Protein
- Hemagglutinins, Viral
- Neuraminidase
- Parainfluenza Virus 1, Human
