Article
High-resolution crystal structure and in vivo function of a kinesin-2 homologue in Giardia intestinalis.
Molecular biology of the cell - 1 Jul 2008
Hoeng J C, Dawson S C, House S A, Sagolla M S, Pham J K, Mancuso J J, Löwe J, Cande W Z
Abstract excerpt
A critical component of flagellar assembly, the kinesin-2 heterotrimeric complex powers the anterograde movement of proteinaceous rafts along the outer doublet of axonemes in intraflagellar transport (IFT). We present the first high-resolution structures of a kinesin-2 motor domain and an ATP hydrolysis-deficient motor domain mutant from the parasitic protist Giardia intestinalis. The high-resolution crystal...
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