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Article

Alpha-adducin Gly460Trp variant increases the risk of stroke in hypertensive Dutch women.

Hypertension (Dallas, Tex. : 1979) - 1 Jun 2008

Zafarmand Mohammad Hadi, van der Schouw Yvonne T, Grobbee Diederick E, de Leeuw Peter W, Bots Michiel L

Abstract excerpt

The Gly460Trp variant of the alpha-adducin gene has been associated with renal sodium retention and salt-sensitive hypertension. Independent of blood pressure, salt sensitivity has been related to cerebrovascular events. We studied the risk of stroke, coronary heart disease (CHD), and myocardial infarction (MI) associated with the alpha-adducin variant and examined the extent to which this risk is modified by the...

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Identifiers

PMID: 18458162
DOI: 10.1161/HYPERTENSIONAHA.108.112458

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