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Article

Altered human CYP3A4 activity caused by Antley-Bixler syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro system.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2012

Moutinho Daniela, Marohnic Christopher C, Panda Satya P, Rueff José, Masters Bettie Sue, Kranendonk Michel

Abstract excerpt

NADPH-cytochrome P450 oxidoreductase (CYPOR) variants have been described in patients with perturbed steroidogenesis and sexual differentiation, related to Antley-Bixler syndrome (ABS). It is important to determine the effect of these variants on CYP3A4, the major drug-metabolizing cytochrome P450 (P450) in humans. In this study, 12 CYPOR_ABS variants were separately coexpressed with CYP3A4 in a robust in vitro...

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Identifiers

PMID: 22252407
DOI: 10.1124/dmd.111.042820
PMCID: PMC3310424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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