Article
A novel non-parametric regression reveals linkage on chromosome 4 for the number of externalizing symptoms in sib-pairs.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2008
Ghosh Saurabh, Bierut Laura J, Porjesz Bernice, Edenberg Howard J, Dick Danielle, Goate Alison, Hesselbrock Victor, Nurnberger John, Foroud Tatiana, Kramer John, Rice John, Begleiter Henri
Abstract excerpt
In this report, we present results of a genome-wide linkage scan using as a phenotype the number of externalizing symptoms associated with alcohol use disorders. Subjects were collected by the Collaborative Study on the Genetics of Alcoholism project from families in which at least three first degree relatives were affected by alcohol dependence. We use a novel non-parametric regression method based on kernel...
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