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Article

Reduced folate carrier polymorphism determines methotrexate uptake by B cells and CD4+ T cells.

Rheumatology (Oxford, England) - 1 Apr 2008

Baslund B, Gregers J, Nielsen C H

Abstract excerpt

OBJECTIVE: To examine if polymorphism 80G --> A in the Reduced Folate Carrier (RFC) affects uptake of MTX in B- and CD4+ T-cells. METHODS: Mononuclear cells were isolated from peripheral blood of healthy persons. Real-time PCR was used to detect the RFC80 variants. FITC-labelled MTX was added to cells stimulated with Candida albicans or tetanus toxoid, and the uptake of MTX was measured by flow cytometry. A...

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PMID: 18316334
DOI: 10.1093/rheumatology/ken073

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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