Article
How to perform meaningful estimates of genetic effects.
PLoS genetics - 2 May 2008
Alvarez-Castro José M, Le Rouzic Arnaud, Carlborg Orjan
Abstract excerpt
Although the genotype-phenotype map plays a central role both in Quantitative and Evolutionary Genetics, the formalization of a completely general and satisfactory model of genetic effects, particularly accounting for epistasis, remains a theoretical challenge. Here, we use a two-locus genetic system in simulated populations with epistasis to show the convenience of using a recently developed model, NOIA, to...
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