Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

<i>MRP7/ABCC10</i>expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer

30 Apr 2008

Abstract excerpt

We used the paclitaxel-resistant human small cell lung cancer subline PC-6/TAX1-1, selected from PC-6 cells by paclitaxel, to test whether MRP7/ABCC10 (ABCC10) confers paclitaxel resistance. We found that gene expression of both ABCB1/MDR1 (ABCB1) and ABCC10 was higher in PC-6/TAX1-1 cells than in PC-6 cells. The expression levels of ABCC10 showed a significant inverse correlation with paclitaxel sensitivity (r =...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer, Lipids, and Metabolism
Share to Drug Transport and Resistance Mechanisms
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18445659
DOI: 10.1158/1535-7163.mct-07-2088

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

<i>MRP7/ABCC10</i>expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancerPMID 18445659Read ↗

Genetic variations in the ATP-binding cassette transporter ABCC10 are associated with neutropenia in Japanese patients with lung cancer treated with nanoparticle albumin-bound paclitaxel.Semantic proximity Read ↗

BRG1 targeting overcomes ABCC-based multidrug resistance induced by paclitaxelSemantic proximity Read ↗

The FOXM1–ABCC5 axis contributes to paclitaxel resistance in nasopharyngeal carcinoma cellsSemantic proximity Read ↗

ABCC11/MRP8 confers pemetrexed resistance in lung cancer.Semantic proximity Read ↗

Genetic variation in the ATP binding cassette transporter ABCC10 is associated with neutropenia for docetaxel in Japanese lung cancer patients cohortSemantic proximity Read ↗

Mechanisms of Resistance to CabazitaxelSemantic proximity Read ↗

ABCC3 as a marker for multidrug resistance in non-small cell lung cancerSemantic proximity Read ↗

Correlation of multidrug resistance with decreased drug accumulation, altered subcellular drug distribution, and increased P-glycoprotein expression in cultured SW-1573 human lung tumor cellsSemantic proximity Read ↗

Single-agent paclitaxel by 3-hour infusion in the treatment of non-small cell lung cancer: links between p53 and K-ras gene status and chemosensitivity.Semantic proximity Read ↗

A selective retinoid X receptor agonist bexarotene (Targretin) prevents and overcomes acquired paclitaxel (Taxol) resistance in human non-small cell lung cancer.Semantic proximity Read ↗

Induction of senescence-like phenotype and loss of paclitaxel sensitivity after wild-type p53 gene transfection of p53-null human non-small cell lung cancer H358 cells.Semantic proximity Read ↗

Cytoskeleton and paclitaxel sensitivity in breast cancer: the role of beta-tubulins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.