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Article

Reduced amelogenin-MMP20 interactions in amelogenesis imperfecta.

Journal of dental research - 1 May 2008

Tanimoto K, Le T, Zhu L, Witkowska H E, Robinson S, Hall S, Hwang P, Denbesten P, Li W

Abstract excerpt

Amelogenin with a proline 41 to threonine mutation (P41T) is hydrolyzed at a lower rate by matrix metalloproteinase 20 (MMP20), resulting in an inherited tooth enamel defect, amelogenesis imperfecta (AI). The aim of this study was to elucidate the effect of P41T on the interactions between amelogenin and MMP20, which may contribute to the formation of this type of AI. The interactions of a recombinant wild-type...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18434575
DOI: 10.1177/154405910808700516
PMCID: PMC3677966

Genes

MMP20
SPR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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