Article
Complex genetic interactions underlying expression differences between Drosophila races: analysis of chromosome substitutions.
Proceedings of the National Academy of Sciences of the United States of America - 29 Apr 2008
Wang Hurng-Yi, Fu Yonggui, McPeek Mary Sara, Lu Xuemei, Nuzhdin Sergey, Xu Anlong, Lu Jian, Wu Mao-Lien, Wu Chung-I
Abstract excerpt
Regulation of gene expression is usually separated into cis and trans components. The separation may become artificial if much of the variation in expression is under multigenic and epistatic (e.g., cis-by-trans) control. There is hence a need to quantify the relative contribution of cis, trans, and cis-by-trans effects on expression divergence at different levels of evolution. To do so across the whole genome,...
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