Article
Quantifying the contribution of genetic variants for survival phenotypes.
Genetic epidemiology - 1 Sept 2008
Müller Martina, Döring Angela, Küchenhoff Helmut, Lamina Claudia, Malzahn Dörthe, Bickeböller Heike, Vollmert Caren, Klopp Norman, Meisinger Christa, Heinrich Joachim, Kronenberg Florian, Wichmann H Erich, Heid Iris M
Abstract excerpt
Particularly in studies based on population representative samples, it is of major interest what impact a genetic variant has on the phenotype of interest, which cannot be answered by mere association estimates alone. One possible measure for quantifying the phenotype's variance explained by the genetic variant is R(2). However, for survival outcomes, no clear definition of R(2) is available in the presence of...
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