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Article

Developmental reprogramming of IGF signaling and susceptibility to endometrial hyperplasia in the rat.

Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2008

McCampbell Adrienne S, Walker Cheryl L, Broaddus Russell R, Cook Jennifer D, Davies Peter J A

Abstract excerpt

In rodents, a brief neonatal exposure of the developing reproductive tract to the xenoestrogen, diethylstilbestrol (DES) reprograms developing tissues to increase susceptibility to tumorigenesis in adult animals, including uterine adenocarcinoma. Progression from a normal endometrium to carcinoma occurs via the intermediate stage of endometrial hyperplasia. We previously reported that endometrial hyperplasia in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18427555
DOI: 10.1038/labinvest.2008.29

Genes

DES

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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