Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts.

European journal of endocrinology - 1 Jul 2008

Lewis Sarah J, Lawlor Debbie A, Nordestgaard Børge G, Tybjaerg-Hansen Anne, Ebrahim Shah, Zacho Jeppe, Ness Andy, Leary Sam, Smith George Davey

Abstract excerpt

OBJECTIVE: Epidemiological studies have shown that low folate levels are associated with a high body mass index (BMI). These findings have potentially important health implications and warrant further investigation to determine whether a causal relationship exists and the direction of this relationship. The methylenetetrahydrofolate reductase (MTHFR) C677T TT genotype is associated with reduced folate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Height
Share to Body Mass Index

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Body Weight

Share to Denmark

Share to Longitudinal Studies

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Surveys and Questionnaires

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 18426813
DOI: 10.1530/EJE-08-0056
PMCID: PMC2772979

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts.PMID 18426813Read ↗

Low folate intake and serum levels are associated with higher body mass index and abdominal fat accumulation: a case control study.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase 677 C->T polymorphism: a link between birth weight and insulin resistance in obese adolescents.Semantic proximity Read ↗

Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity?Semantic proximity Read ↗

Association of MTHFR C677T with Obesity in Human Female PopulationSemantic proximity Read ↗

rs9939609 FTO genotype associations with FTO methylation level influences body mass and telomere length in an Australian rural population.Semantic proximity Read ↗

The MTHFR gene polymorphism is associated with lean body mass but not fat body mass.Semantic proximity Read ↗

Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects.Semantic proximity Read ↗

Common polymorphisms in six genes of the methyl group metabolism pathway and obesity in European adolescents.Semantic proximity Read ↗

Alanine amino transferase concentrations are linked to folate intakes and methylenetetrahydrofolate reductase polymorphism in obese adolescent girls.Semantic proximity Read ↗

The 677C→T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish populationSemantic proximity Read ↗

Maternal folate-related gene environment interactions and congenital heart defects.Semantic proximity Read ↗

Metabolic syndrome and insulin resistance in schizophrenia patients receiving antipsychotics genotyped for the methylenetetrahydrofolate reductase (MTHFR) 677C/T and 1298A/C variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.