Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects.

International journal of molecular sciences - 26 May 2015

Fan Shu-Jun, Yang Bo-Yi, Zhi Xue-Yuan, He Miao, Wang Da, Wang Yan-Xun, Wang Yi-Nuo, Wei Jian, Zheng Quan-Mei, Sun Gui-Fan

Abstract excerpt

Several studies have examined the associations of methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G polymorphisms with being overweight/obesity. However, the results are still controversial. We therefore conducted a case-control study (517 cases and 741 controls) in a Chinese Han population and then performed a meta-analysis by combining previous studies (5431 cases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asian People
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferredoxin-NADP Reductase

Share to Genetic Association Studies

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Obesity

Share to Overweight

Source

Open in PubMed Open full text

Identifiers

PMID: 26016497
DOI: 10.3390/ijms160611849
PMCID: PMC4490418

Genes

MTRR
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Are MTHFR C677T and MTRR A66G Polymorphisms Associated with Overweight/Obesity Risk? From a Case-Control to a Meta-Analysis of 30,327 Subjects.PMID 26016497Read ↗

Gender-specific interactions of MTHFR C677T and MTRR A66G polymorphisms with overweight/obesity on serum lipid levels in a Chinese Han population.Semantic proximity Read ↗

Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms with Being Overweight/Obesity on the Risk of Type 2 Diabetes.Semantic proximity Read ↗

Genetic variants in the MC4R gene and risk of obesity/overweight: A systematic review and meta-analysis.Semantic proximity Read ↗

Association between MC4R rs17782313 genotype and obesity: A meta-analysis.Semantic proximity Read ↗

Association of MTHFR C677T with Obesity in Human Female PopulationSemantic proximity Read ↗

Association between common polymorphism near the MC4R gene and obesity risk: a systematic review and meta-analysis.Semantic proximity Read ↗

The rs17782313 polymorphism near MC4R gene confers a high risk of obesity and hyperglycemia, while PGC1α rs8192678 polymorphism is weakly correlated with glucometabolic disorder: a systematic review and meta-analysis.Semantic proximity Read ↗

Prevalence, associated factors, and gene polymorphisms of obesity in Tibetan adults in Qinghai, China.Semantic proximity Read ↗

Association of MTHFR C677T gene polymorphism with metabolic syndrome in a Chinese population: a case-control study.Semantic proximity Read ↗

Are genetic variants of the methyl group metabolism enzymes risk factors predisposing to obesity?Semantic proximity Read ↗

Associations Between Obesity-Related Gene MC4R rs17782313 Locus Polymorphism and Components of Metabolic Syndrome: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

The Impact of Variants in Four Genes: MC4R, FTO, PPARG and PPARGC1A in Overweight and Obesity in a Large Sample of the Brazilian Population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.