Article
Phenotypical and functional study of ghrelin and its receptor in the pathogenesis of Crohn's disease.
Inflammatory bowel diseases - 1 Sept 2008
Hosomi Shuhei, Oshitani Nobuhide, Kamata Noriko, Sogawa Mitsue, Yamagami Hirokazu, Watanabe Kenji, Tominaga Kazunari, Watanabe Toshio, Fujiwara Yasuhiro, Maeda Kiyoshi, Hirakawa Kosei, Arakawa Tetsuo
Abstract excerpt
BACKGROUND: Ghrelin, a novel endogenous ligand for the growth hormone secretagogue receptor (GHSR), has been demonstrated to possess multiple functions including antiinflammatory effects. The aim of this study was to investigate the expression of ghrelin and GHSR and the function of ghrelin in inflammatory bowel disease (IBD). METHODS: The expression of ghrelin and GHSR mRNA was quantified in mucosal biopsy...
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