Article
Polyglutamine disease: from pathogenesis to therapy.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde - 2 Mar 2012
Watson Lauren M, Scholefield Janine, Greenberg L Jacquie, Wood Matthew J A
Abstract excerpt
Polyglutamine diseases are inherited neurodegenerative conditions arising from expanded trinucleotide CAG repeats in the disease-causing gene, which are translated into polyglutamine tracts in the resultant protein. Although these diseases share a common type of mutation, emerging evidence suggests that pathogenesis is complex, involving disruption of key cellular pathways, and varying with the disease context....
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