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Article

Therapeutic gene silencing strategies for polyglutamine disorders.

Trends in genetics : TIG - 1 Jan 2010

Scholefield Janine, Wood Matthew J A

Abstract excerpt

Dominantly inherited polyglutamine disorders are chronic neurodegenerative diseases therapeutically amenable to gene-specific silencing strategies. Several compelling nucleic acid-based approaches have recently been developed to block the expression of mutant proteins and prevent toxic neurodegenerative sequelae. With such approaches, avoiding potential side effects caused by the concomitant ablation of the...

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PMID: 19962779
DOI: 10.1016/j.tig.2009.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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