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Article

Promoter hypermethylation of FANCF and outcome in advanced ovarian cancer

1 Apr 2008

Abstract excerpt

The Fanconi gene family has a role in DNA repair and inactivation of FANCF has been proposed as a mechanism of sensitisation to platinum chemotherapy. This study sought to confirm this hypothesis in cell lines and a large series of ovarian cancer samples. Promoter methylation was assessed by methylation-sensitive polymerase chain reaction of FANCF in nine ovarian cancer cell lines and 74 ovarian cancer samples...

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Share to DNA Repair Mechanisms
Share to Epigenetics and DNA Methylation
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18414472
DOI: 10.1038/sj.bjc.6604325

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