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Article

RB status governs differential sensitivity to cytotoxic and molecularly-targeted therapeutic agents

15 Apr 2008

Abstract excerpt

The retinoblastoma tumor suppressor (RB) is frequently inactivated in human cancers and has been shown to modulate the anti-proliferative effects of DNA-damaging therapies. However, the impact of RB loss on response to disparately functioning cytotoxic agents as well as targeted therapies is poorly understood. Here 3T3-immortalized and Ras-transformed mouse adult fibroblasts (MAFs) containing conditional RB...

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PMID: 18414045
DOI: 10.4161/cc.7.8.5737

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