Article
Combinatorial antibody libraries from survivors of the Turkish H5N1 avian influenza outbreak reveal virus neutralization strategies.
Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2008
Kashyap Arun K, Steel John, Oner Ahmet F, Dillon Michael A, Swale Ryann E, Wall Katherine M, Perry Kimberly J, Faynboym Aleksandr, Ilhan Mahmut, Horowitz Michael, Horowitz Lawrence, Palese Peter, Bhatt Ramesh R, Lerner Richard A
Abstract excerpt
The widespread incidence of H5N1 influenza viruses in bird populations poses risks to human health. Although the virus has not yet adapted for facile transmission between humans, it can cause severe disease and often death. Here we report the generation of combinatorial antibody libraries from the bone marrow of five survivors of the recent H5N1 avian influenza outbreak in Turkey. To date, these libraries have...
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