Article
Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantation.
Transplantation - 15 Apr 2008
Fiorina Paolo, Jurewicz Mollie, Vergani Andrea, Augello Andrea, Paez Jesus, Ricchiuti Vincent, Tchipachvili Vaja, Sayegh Mohamed H, Abdi Reza
Abstract excerpt
BACKGROUND: Trafficking of dendritic cells (DC), the primary regulators of alloimmune responses, is controlled by chemokines. Here, we provide evidence that lack of CCR2 could lead to the generation of functionally and phenotypically different DC, which in part could explain the benefits observed in transplanting islets in CCR2 recipients. METHODS AND RESULTS: We show that, in contrast to the in vitro DC...
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