Article
FBXL21 association with schizophrenia in Irish family and case-control samples.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Oct 2008
Chen Xiangning, Wang Xu, Sun Cuie, Chen Qi, O'Neill F Anthony, Walsh Dermot, Fanous Ayman, Kendler Kenneth S
Abstract excerpt
FBXL21 gene encodes an F-box containing protein functioning in the SCF ubiquitin ligase complex. The role of the F-box protein is to recruit proteins designated for degradation to the ligase complex so they would be ubiquitinated. Using both family and case-control samples, we found consistent associations in and around FBXL21 gene. In the family sample (Irish study of high density schizophrenia families, ISHDSF,...
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