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Article

A novel phenotypic method to determine fludarabine triphosphate accumulation in T-lymphocytes from hematopoietic cell transplantation patients.

Cancer chemotherapy and pharmacology - 1 Feb 2009

Woodahl Erica L, Wang Joanne, Heimfeld Shelly, Sandmaier Brenda M, O'Donnell Paul V, Phillips Brian, Risler Linda, Blough David K, McCune Jeannine S

Abstract excerpt

PURPOSE: Fludarabine is an integral anticancer agent for patients with chronic lymphocytic leukemia (CLL) and those receiving conditioning regimens prior to allogeneic hematopoietic cell transplantation (HCT). An individual's response to fludarabine may be influenced by the amount of CD4(+) and CD8(+) T-lymphocyte suppression. Fludarabine undergoes cellular uptake and activation to form the cytotoxic metabolite,...

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Identifiers

PMID: 18398611
DOI: 10.1007/s00280-008-0748-0
PMCID: PMC6708594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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