Article
Negative correlation between brain glutathione level and negative symptoms in schizophrenia: a 3T 1H-MRS study.
PloS one - 9 Apr 2008
Matsuzawa Daisuke, Obata Takayuki, Shirayama Yukihiko, Nonaka Hiroi, Kanazawa Yoko, Yoshitome Eiji, Takanashi Junichi, Matsuda Tsuyoshi, Shimizu Eiji, Ikehira Hiroo, Iyo Masaomi, Hashimoto Kenji
Abstract excerpt
BACKGROUND: Glutathione (GSH), a major intracellular antioxidant, plays a role in NMDA receptor-mediated neurotransmission, which is involved in the pathophysiology of schizophrenia. In the present study, we aimed to investigate whether GSH levels are altered in the posterior medial frontal cortex of schizophrenic patients. Furthermore, we examined correlations between GSH levels and clinical variables in...
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