Article
Two domains of the epidermal growth factor receptor are involved in cytoskeletal interactions.
Biochemical and biophysical research communications - 13 Jun 2008
Song Wei, Wu Jing, Ge Gaoxiang, Lin Qishui
Abstract excerpt
Epidermal growth factor receptor can interact directly with F-actin through an actin-binding domain. In the present study, a mutant EGFR, lacking a previously identified actin-binding domain (ABD 1), was still able to bind elements of the cytoskeleton. A second EGFR actin-binding domain (ABD 2) was identified in the region of the receptor that includes Tyr-1148 by a yeast two-hybrid assay. GST fusion proteins...
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