Article
Effector Antitumor and Regulatory T Cell Responses Influence the Development of Nonmelanoma Skin Cancer in Kidney Transplant Patients.
Transplantation - 1 Sept 2017
Crespo Elena, Fernandez Loreto, Lúcia Marc, Melilli Edoardo, Lauzurica Ricardo, Penin Rosa Maria, Quer Ariadna, Luque Sergio, Quero Maria, Manonelles Anna, Torras Joan, Cruzado Josep Maria, Cañas Laura, Grinyó Josep Maria, Bestard Oriol
Abstract excerpt
BACKGROUND: Chronic immunosuppression promotes nonmelanocytic squamous cell carcinoma (SCC) after kidney transplantation. Adaptive and innate immunity play a key role controlling tumor growth and are influenced by different immunosuppressive agents. We hypothesized that functional impairment of tumor-specific T cell responses due to calcineurin inhibitors (CNI) could contribute to SCC development, whereas...
Topics
- Aged
- Antigens, Neoplasm
- Calcineurin Inhibitors
- Carcinoma, Squamous Cell
- Case-Control Studies
- Cross-Sectional Studies
- Cytokines
- Drug Substitution
- Drug Therapy, Combination