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Article

Early and accurate prediction of Peg-IFNs/ribavirin therapy outcome in the individual patient with chronic hepatitis C by modeling the dynamics of the infected cells.

Clinical pharmacology and therapeutics - 1 Aug 2008

Colombatto P, Ciccorossi P, Maina A M, Civitano L, Oliveri F, Coco B, Romagnoli V, Bonino F, Brunetto M R

Abstract excerpt

A novel biomathematical model that analyzes the combined alanine transaminase (ALT) and viral-load kinetics during the first month of pegylated interferon (Peg-IFN) plus ribavirin (RBV) therapy was successfully applied in 90 of 97 (93%) chronic hepatitis C patients in order to compute the number of infected cells at the end of therapy (I(eot)). The I(eot) indices were lower in sustained virological responders...

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Identifiers

PMID: 18388885
DOI: 10.1038/clpt.2008.21

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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