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Article

Mutation that dramatically alters rat titin isoform expression and cardiomyocyte passive tension.

Journal of molecular and cellular cardiology - 1 Jun 2008

Greaser Marion L, Warren Chad M, Esbona Karla, Guo Wei, Duan Yingli, Parrish Amanda M, Krzesinski Paul R, Norman Holly S, Dunning Sandra, Fitzsimons Daniel P, Moss Richard L

Abstract excerpt

Titin is a very large alternatively spliced protein that performs multiple functions in heart and skeletal muscles. A rat strain is described with an autosomal dominant mutation that alters the isoform expression of titin. While wild type animals go through a developmental program where the 3.0 MDa N2B becomes the major isoform expressed by two to three weeks after birth (approximately 85%), the appearance of the...

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Source

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Identifiers

PMID: 18387630
DOI: 10.1016/j.yjmcc.2008.02.272
PMCID: PMC2501117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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