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Article

Mitochondrial tRNALeu/Lys and ATPase 6/8 gene variations in spinocerebellar ataxias.

Neuro-degenerative diseases - 1 Jan 2009

Safaei Sepideh, Houshmand Massoud, Banoei Mohammad Mehdi, Panahi Mehdi Shafa Shariat, Nafisi Shahriar, Parivar Kazem, Rostami Maryam, Shariati Parvin

Abstract excerpt

BACKGROUND: The spinocerebellar ataxias (SCA) comprise a heterogeneous group of severe late-onset neurodegenerative diseases that are promoted by the expansion of a tandem-arrayed DNA sequence that modifies the primary structure of the protein. METHODS: Genomic DNA of 20 patients affected with SCAs was extracted from peripheral blood and screened for deletions in mitochondrial DNA (mtDNA). Sequencing of...

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PMID: 19066432
DOI: 10.1159/000170885

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