Article
Loss of the eukaryotic initiation factor 3f in melanoma.
Molecular carcinogenesis - 1 Oct 2008
Doldan Adriana, Chandramouli Anupama, Shanas Reneé, Bhattacharyya Achyut, Leong Stanley P L, Nelson Mark A, Shi Jiaqi
Abstract excerpt
Aberrant regulation of the translation initiation is known to contribute to tumorigenesis. eIF3 plays an important role in translation initiation. eIF3f is the p47 subunit of the eIF3 complex whose function in cancer is not clear. Initial studies from our group indicated that eIF3f expression is decreased in melanoma. Overexpression of eIF3f inhibits translation and induces apoptosis in melanoma cells. The eIF3f...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.