Article
[Factors affecting initial virologic response and emergence of resistant mutants after adefovir treatment in lamivudine-resistant chronic hepatitis B patients].
The Korean journal of hepatology - 1 Mar 2008
Cho Jin Hee, Cheong Jae Youn, Kang Joon Koo, Park Jin Sun, Lee Myoung Hee, Lim Nam Kyu, Hong Sun Pyo, Kim Soo-Ok, Yoo Wang Don, Cho Sung Won
Abstract excerpt
BACKGROUND/AIMS: Adefovir dipivoxil (adefovir) effectively inhibits both wild-type and lamivudine-resistant hepatitis B virus (HBV) replication. The development of adefovir resistance is both delayed and infrequent compared with lamivudine resistance. The aim of this study was to characterize the serologic, biochemical, and virologic response to adefovir, and to explore the factors affecting initial virologic...
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