Article
Substrate binding, deprotonation, and selectivity at the periplasmic entrance of the Escherichia coli ammonia channel AmtB.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2008
Javelle Arnaud, Lupo Domenico, Ripoche Pierre, Fulford Tim, Merrick Mike, Winkler Fritz K
Abstract excerpt
The conduction mechanism of Escherichia coli AmtB, the structurally and functionally best characterized representative of the ubiquitous Amt/Rh family, has remained controversial in several aspects. The predominant view has been that it facilitates the movement of ammonium in its uncharged form as indicated by the hydrophobic nature of a pore located in the center of each subunit of the homotrimer. Using...
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