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Article

Mutations in the RAM network confer resistance to the thiol oxidant 4,4'-dipyridyl disulfide.

Molecular genetics and genomics : MGG - 1 Jun 2008

López-Mirabal H Reynaldo, Winther Jakob R, Thorsen Michael, Kielland-Brandt Morten C

Abstract excerpt

Thiol oxidants are expected to have multiple effects in living cells. Hence, mutations giving resistance to such agents are likely to reveal important targets and/or mechanisms influencing the cellular capacity to withstand thiol oxidation. A screen for mutants resistant to the thiol-specific oxidant dipyridyl disulfide (DPS) yielded tao3-516, which is impaired in the function of the RAM signaling network protein...

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PMID: 18357467
DOI: 10.1007/s00438-008-0339-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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