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Article

High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector.

The Journal of clinical investigation - 1 Apr 2008

Zhang Xiao-Bing, Beard Brian C, Trobridge Grant D, Wood Brent L, Sale George E, Sud Reeteka, Humphries R Keith, Kiem Hans-Peter

Abstract excerpt

Retroviral vector-mediated HSC gene therapy has been used to treat individuals with a number of life-threatening diseases. However, some patients with SCID-X1 developed retroviral vector-mediated leukemia after treatment. The selective growth advantage of gene-modified cells in patients with SCID...

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Source

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Identifiers

PMID: 18357342
DOI: 10.1172/JCI34371
PMCID: PMC2268879

Genes

HOXB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18357342-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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