Article
Basophil phenotypes in chronic idiopathic urticaria in relation to disease activity and autoantibodies.
The Journal of investigative dermatology - 1 Aug 2008
Eckman John A, Hamilton Robert G, Gober Laura M, Sterba Patricia M, Saini Sarbjit S
Abstract excerpt
Potentially pathogenic IgG autoantibodies to IgE or its receptor, Fc epsilonRIalpha, have been detected in approximately 40% of chronic idiopathic urticaria (CIU) patients. CIU patients' basophils display distinct altered Fc epsilonRIalpha-mediated degranulation. CIU patients with basophil histamine release in response to polyclonal goat anti-human IgE > or = 10% are classified as CIU responders (CIU-R) and < 10%...
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