Secretion of cytokines, histamine and leukotrienes in chronic urticaria.

doi:10.1159/000066772

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Article

Secretion of cytokines, histamine and leukotrienes in chronic urticaria.

International archives of allergy and immunology - 1 Nov 2002

Ferrer Marta, Luquin Esther, Sanchez-Ibarrola Alfonso, Moreno Cristina, Sanz Maria L, Kaplan Allen P

Abstract excerpt

BACKGROUND: Approximately 35-40% of patients with chronic urticaria have an IgG autoantibody to the IgE receptor which can activate basophils and mast cells so that they release histamine. In this study we assessed the cytokine profile present in chronic urticaria sera, and then measured cytokine and leukotriene release from basophils and mast cells upon incubation with chronic urticaria sera. Finally we assessed...

Topics

Adult
Aged
Antibodies, Anti-Idiotypic
Basophils
Chronic Disease
Cytokines
Female
Histamine
Humans
Immunoblotting
Interleukin-4
Leukotrienes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mast Cells

Middle Aged

Phenotype

Tetradecanoylphorbol Acetate

Urticaria

Source

Open in PubMed

Identifiers

PMID: 12444324
DOI: 10.1159/000066772

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