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Article

ACTH receptor promoter polymorphism associates with severity of premature adrenarche and modulates hypothalamo-pituitary-adrenal axis in children.

Pediatric research - 1 Apr 2008

Lappalainen Saila, Utriainen Pauliina, Kuulasmaa Tiina, Voutilainen Raimo, Jääskeläinen Jarmo

Abstract excerpt

The genetic mechanisms underlying the regulation of adrenarche are unknown. The aim of the study was to find out whether ACTH receptor (MC2R) promoter polymorphism associates with premature adrenarche (PA) and its characteristics. DNA samples of 74 prepubertal children with PA and their age- and gender-matched 97 healthy controls were genotyped for the -2 bp T/C diallelic MC2R promoter polymorphism (MC2R -2 T>C)...

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Share to Adrenocorticotropic Hormone
Share to Dehydroepiandrosterone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydrocortisone

Share to Hypothalamo-Hypophyseal System

Share to Pituitary-Adrenal System

Share to Promoter Regions, Genetic

Share to Puberty, Precocious

Share to Receptors, Corticotropin

Source

Identifiers

PMID: 18356748
DOI: 10.1203/PDR.0b013e3181659c14

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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