Article
Polymorphism Pro12Ala of PPARG in prepubertal children with premature adrenarche and its association with growth in healthy children.
Hormone research in paediatrics - 1 Jan 2010
Laakso Saila, Utriainen Pauliina, Laakso Markku, Voutilainen Raimo, Jääskeläinen Jarmo
Abstract excerpt
BACKGROUND: The peroxisome proliferator-activated receptor-γ2 (PPARγ2) participates in the regulation of insulin sensitivity, and has connections to the GH-IGF system and ACTH-adrenal androgen axis. We hypothesized that PPARG Pro12Ala polymorphism leading to decreased receptor activity could contribute to the premature onset of adrenarche (PA). METHODS: We performed a cross-sectional association study in 73...
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