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Article

Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism.

Clinical chemistry - 1 May 2008

Smith Andrew J P, D'Aiuto Francesco, Palmen Jutta, Cooper Jackie A, Samuel Jane, Thompson Simon, Sanders Julie, Donos Nikos, Nibali Luigi, Brull David, Woo Pat, Humphries Steve E

Abstract excerpt

BACKGROUND: Interleukin-6 (IL-6) concentrations vary substantially among individuals. This study aimed to identify novel genetic markers to explain these differences. METHODS: We sequenced a region 6-kb upstream of the IL6 [interleukin 6 (interferon, beta 2)] transcription start site in a search for functional variants and detected 3 common variants: -6331T>C, -6101A>T, and -5617/-5616C/A>T/G. IL6 -6331T>C (C...

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Identifiers

PMID: 18356242
DOI: 10.1373/clinchem.2007.098608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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