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Article

Human CD4(+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4(+) T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2008

Alisa Akeel, Boswell Sandra, Pathan Ansar A, Ayaru Lakshmana, Williams Roger, Behboudi Shahriar

Abstract excerpt

There is limited information on the influence of tumor growth on the expansion of tumor-specific TGF-beta-producing CD4(+) T cells in humans. alpha-Fetoprotein (AFP) is an oncofetal Ag and has intrinsic immunoregulatory properties. In this study, we report the identification and characterization of subsets of CD4(+) T cells that recognize an epitope within the AFP sequence (AFP(46-55)) and develop into...

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Share to alpha-Fetoproteins
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD4-Positive T-Lymphocytes

Share to CTLA-4 Antigen

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Source

Identifiers

PMID: 18354237
DOI: 10.4049/jimmunol.180.7.5109

Genes

AFP
TNR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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