Article
Two seemingly homologous noncoding RNAs act hierarchically to activate glmS mRNA translation.
PLoS biology - 18 Mar 2008
Urban Johannes H, Vogel Jörg
Abstract excerpt
Small noncoding RNAs (sRNA) can function as posttranscriptional activators of gene expression to regulate stress responses and metabolism. We here describe the mechanisms by which two sRNAs, GlmY and GlmZ, activate the Escherichia coli glmS mRNA, coding for an essential enzyme in amino-sugar metabolism. The two sRNAs, although being highly similar in sequence and structure, act in a hierarchical manner. GlmZ,...
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