Article
Remodeling of airway walls in fatal asthmatics decreases lymphatic distribution; beyond thickening of airway smooth muscle layers.
Allergology international : official journal of the Japanese Society of Allergology - 1 Jun 2008
Ebina Masahito
Abstract excerpt
BACKGROUND: We previously reported the phenotypic distribution patterns of airway smooth muscles in fatal asthmatics; Type I asthmatics with smooth muscle bundle thickening only in large airways and Type II in whole airways. We hypothesized that increased smooth muscle bundles in the airway walls would disrupt airway lymphatics to impair airway clearance in these fatal asthmatics. METHODS: The autopsy lungs of...
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