Article
Real-time PCR/MCA assay using fluorescence resonance energy transfer for the genotyping of resistance related DHPS-540 mutations in Plasmodium falciparum.
Malaria journal - 17 Mar 2008
Mens Petra F, van Overmeir Chantal, Bonnet Maryline, Dujardin Jean-Claude, d'Alessandro Umberto
Abstract excerpt
BACKGROUND: Sulphadoxine-pyrimethamine has been abandoned as first- or second-line treatment by most African malaria endemic countries in favour of artemisinin-based combination treatments, but the drug is still used as intermittent preventive treatment during pregnancy. However, resistance to sulphadoxine-pyrimethamine has been increasing in the past few years and, although the link between molecular markers and...
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