Article
COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C > T in its "frizzled" motif is associated with obesity in diabetes type 2 patients.
Anais da Academia Brasileira de Ciencias - 1 Mar 2008
Errera Flavia I V, Canani Luís H, Yeh Erika, Kague Erika, Armelin-Corrêa Lucia M, Suzuki Oscar T, Tschiedel Balduíno, Silva Maria Elizabeth R, Sertié Andréa L, Passos-Bueno Maria Rita
Abstract excerpt
Collagen XVIII can generate two fragments, NC11-728 containing a frizzled motif which possibly acts in Wnt signaling and Endostatin, which is cleaved from the NC1 and is a potent inhibitor of angiogenesis. Collagen XVIII and Wnt signaling have recently been associated with adipogenic differentiat...
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